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Nolvadex is an antiestrogen medication used to decrease the risk of developing breast cancer in women with high risk of developing one, and in women with ductal carcinoma in situ (DCIS) after radiation or surgery. The medication is also used as a part of combination therapy for treating different types of breast cancer, as well as for treatment of breast cancer spread to other sites in the body. Nolvadex acts by blocking the effect of estrogen in some tumors (those activated by estrogen), preventing their growth.

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Competitively binds to estrogen receptors in target organs, like estrogen receptor translocates with the nucleus of tumor cells and thus blocks the action of estrogen.


Well absorbed from the gastrointestinal tract, Tmax - 4-7 h, the time to Css - 3-4 weeks. Binding to Buy Cheap Nolvadex Online plasma proteins - 99 %. Metabolized in the liver by hydroxylation and demethylation. Excretion is biphasic with an initial T1 / 2 - 7-14 hours and the subsequent slow terminal T1 / 2 - 7 days. Cheap Nolvadex For Sale Excreted mainly via the intestine, mainly in the form of metabolites, a small amount - the kidneys.

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Hypersensitivity, pregnancy, breast-feeding .

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Cardio- vascular system and blood (blood, hemostasis ) thrombophlebitis, thromboembolism, transient leukopenia, thrombocytopenia.

From the digestive tract. abdominal pain, nausea, vomiting, loss of appetite, constipation, increased liver enzymes, severe liver (cholestasis, hepatitis) .

Genitourinary. bleeding or vaginal discharge, amenorrhea, or irregular menstruation in premenopausal patients, the occurrence of reversible cystic ovarian tumors, fluid retention, itching in the genital area .

Allergic reactions. skin rash .

Other. alopecia, pain in the area of the lesion and / or bone, increasing the size of soft tissue structures ( accompanied by severe erythema lesions and surrounding areas ), hypercalcemia, hot flashes, increased body temperature, with prolonged use - cases of endometrial changes including hyperplasia polyps, intrauterine fibroids and in rare cases - endometrial cancer .

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